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SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASE

September 15-18, 1996
Brussells, Belgium

SCIENTIFIC PROGRAM
(Oral Abstracts)

Hormonal effects of Soy
Postmenopausal Studies

Dietary Flour Supplementation Decreases Post-Menopausal Hot Flushes: Effect of Soy and Wheat
Murkies, A.L.1,3*, Lombard, C.1, Strauss, B.J.G.2, Wilcox, G.4, Burger H.G.3, Morton, M.S.5.

1 Brighton Medical Clinic, 26 Carpenter St., Brighton 3186 Vic., Jean Hailes Foundation, Clayton Rd., Clayton Vic 3168 Australia
2 Clinical Nutrition and Metabolism Unit, Monash Medical Centre, Clayton Rd., Clayton 3168 Vic. Australia
3 Prince Henry's Institute of Medical Research, Monash Medical Centre, Clayton Rd., Clayton 3168 Vic. Australia
4 Registrar in Diabetes and Metabolism, Caulfield General Medical Centre, Caulfield, Vic. Australia
5Tenovus Cancer Research Centre, University of Wales, College of Medicine, Cardiff, Wales

Plants contain compounds with oestrogen-like action called phytoestrogens. Soy contains daidzin, a potent phytoestrogen, and wheat flour contains less potent enterolactones. Soy flour supplementation improves vaginal maturation index in postmenopausal women. We aimed to show in 58 postmenopausal women (age 54 range 30-70 years) with at least 14 hot flushes per week, that their daily diet supplemented with 45 gm of soy flour (n=28) could reduce flushes compared with 45 gm of wheat flour (n=30) over twelve weeks when randomized and double blind. In a general practice setting, with an enthusiastic dietition, hot flushes significantly decreased in the soy and wheat flour groups (40% and 25% reduction respectively p<.001 for both) with a significant rapid response in the soy flour group in six weeks (p<.001) that continued. Menopausal symptom score decreased significantly in both groups (p<.05). Urinary daidzein confirmed compliance (p<0.001), and with urinary equol and enterolactone increased significantly within the soy supplemented group (p). Vaginal cell maturation, plasma lipids, urinary calcium remained unchanged. Serum FSH decreased and urinary hydroxyproline increased in the wheat flour group. Soy and wheat flour supplementation reduce hot flushes with soy producing a more rapid response. Soy flour substitutes may be used as an aid in the treatment of hot flushes in some women.

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