Scientific Program (Oral Abstracts) | Poster Abstracts | Speaker List
SECOND INTERNATIONAL SYMPOSIUM
ON THE ROLE OF SOY
IN PREVENTING AND TREATING CHRONIC DISEASESeptember 15-18, 1996
Brussells, Belgium
SCIENTIFIC PROGRAM
(Oral Abstracts)Soy and Cancer
Soy Consumption and Cancer Risk : Human StudiesEvaluation of Soy Protein in Risk Reduction for Colon Cancer and Cardiovascular Disease: Preliminary Results
Maurice R. Bennink, J.E. Mayle, L.D. Bourquin and D. Thiagarajan.
Michigan State University, East Lansing, MI 48824-1224, USA.A double-blind, prospective study was conducted to determine if soy protein could reduce indicators of risk for colon cancer and cardiovascular disease. Subjects were recruited from a population of patients with previously-confirmed adenomatous colon polyps or colon cancer. Seventy patients, 41 males and 29 females, ages 33 to 69 (33-39 yr, 5; 40-49 yr, 10; 50-59, 16; 60-69, 39) entered the study.
Subjects (60) consumed either a soy or casein (control) supplement for 1 year. The supplements provided 38 g of protein and 204 kcal per day. In addition, the subjects provided 4 blood samples (2 before, 6 mo. and end) and 8 colon mucosa biopsy sampled (4 before and 4 at the end). Blood samples are being analyzed for lipids, apolipoproteins, thyroxine, thyroid stimulating hormone, clotting time and routine clinical measurements. Urine samples were analyzed bi-monthly for isoflavone excretion for compliance monitoring. Ten subjects did not consume the supplements (negative controls), but provided colon biopsies. The biopsies from the sigmoid colon are being evaluated for proliferation patterns, mitotic frequency, and protein-tyrosine kinase activity.
Only preliminary results will be reported. Subject compliance, as monitored by isoflavone excretion in urine, was excellent ( 96%). Some, but not all, subjects consuming soy protein had a reduction in total cholesterol. Most of this reduction was due to lower LDL and VLDL cholesterol, HDL cholesterol did not change. Thyroxine and thyroid stimulating hormone did not change with soy consumption.Data for proliferating cellular nuclear antigen (a marker for assessing mucosal proliferative status and risk for colon cancer) and for tyrosine kinase activity will be reported.
(Support for this study was provided by the United Soybean Board, supplement was provided by Protein Technologies, International).
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